Saturday, April 30, 2011

Treatments for ulcerative colitis

TREATMENT
Both medications and surgery have been used to treat ulcerative colitis. However, surgery is reserved for those with severe rousing and life-threatening complications. There is no medication that can cure ulcerative colitis. Patients with ulcerative redness will typically undergo periods of relapse (worsening of inflammation) followed by periods of remission (resolution of inflammation) lasting months to years. 


During relapses, symptoms of abdominal pain, diarrhea, and rectal injury worsen. During remissions, these symptoms subside. Remissions usually occur because of communication with medications or surgery, but occasionally they occur spontaneously, that is, without some treatment.

Medications treating ulcerative redness allow 1) anti-inflammatory agents such as 5-ASA compounds, systemic corticosteroids, topical corticosteroids, and 2) immunomodulators.

Anti-inflammatory medications that modification intestinal rousing are analogous to arthritis medications that modification render rousing (arthritis). The anti-inflammatory medications that are used in the communication of ulcerative redness are:

Immunomodulators are medications that suppress the body's insusceptible system either by reaction the cells that are responsible for immunity, or by interfering with proteins that are important in promoting inflammation. Immunomodulators increasingly are becoming important treatments for patients with severe ulcerative redness who do not move adequately to anti-inflammatory agents. Examples of immunomodulators allow 6-mercaptopurine (6-MP), azathioprine (Imuran), methotrexate (Rheumatrex, Trexall), cyclosporine (Gengraf, Neoral).

SURGERY

If fasting and lifestyle changes, drug therapy or other treatments don't assuage your signs and symptoms, your doctor may propose surgery.
Surgery can often decimate ulcerative colitis. But that usually means removing your whole colon and rectum (proctocolectomy). In the past, after this surgery you would dress a small bag over an opening in your cavum (ileostomy) to collect stool. But a procedure titled ileoanal anastomosis eliminates the need to dress a bag. Instead, your doc constructs a pouch from the modify of your small intestine. The pouch is then attached directly to your anus. This allows you to expel squander more normally, although you may hit more-frequent viscus movements that are soft or watery because you no individual hit your colon to absorb water.

If you hit surgery, communicate your doctor whether an ileostomy or an ileoanal pouch is correct for you. Between 25 and 40 proportionality of people with ulcerative colitis eventually need surgery.

COMPLICATIONS 


These include toxic dilatation .haemmorrhage ,stricture and perforation .Carcinomas may occur ,the overall incidence being around 2% .However ,in patients who have had the disease for over 25 years this rises to 10 %.Factors associated with higher risk inclde onset in childhood , a severe first attack ,total colonic involvement ,and contineuos rather that intermittent symptoms .Extracolonic complications include seronegative arthritis ( sacroilitis ,ankylosing spondylitis) sclerosing cholangitis ,cirrhosis ,pericholangitis ,iritis uveitis ,episcleritis erythema nodosum ,pyodera gangrenosum ,and apthous stomatitis .Rarely , systemic amloidosis may occur.






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